| Player | Birth date | First year in majors | Last year in majors | Played in majors | With StL-N | With minors | Drafted |
| Gerald Zornow | March 3, 1916 | 0 | 0 | No | No | Yes | 0 |
| Al Zuber | May 1, 1927 | 0 | 0 | No | No | Yes | 0 |
| Robert Zuccarini | December 15, 1933 | 0 | 0 | No | No | Yes | 0 |
| Zach Zuercher | April 10, 1984 | 0 | 0 | No | No | Yes | 2005 |
| Emory Zumbro | February 9, 1903 | 0 | 0 | No | No | Yes | 0 |
| Guillermo Zuniga | October 10, 1998 | 2023 | 2023 | Yes | Yes | Yes | 0 |
| Vidal Zunigha | 0 | 0 | No | No | Yes | 0 | |
| Gary Zunino | 1957 | 0 | 0 | No | No | Yes | 0 |
| George Zuverink | August 20, 1924 | 1951 | 1959 | Yes | No | Yes | 0 |
| Fred Zweifel | January 5, 1950 | 0 | 0 | No | No | Yes | 1971 |
| Ivan de Jesus | January 9, 1953 | 1974 | 1988 | Yes | Yes | Yes | 0 |
| Francisco de la Rosa | March 3, 1966 | 1991 | 1991 | Yes | No | Yes | 0 |