| Player | Birth date | First year in majors | Last year in majors | Played in majors | With StL-N | With minors | Drafted |
| Len Picota | July 23, 1966 | 0 | 0 | No | No | Yes | 0 |
| Stan Piela | 0 | 0 | No | No | Yes | 0 | |
| Knowles Piercey | January 31, 1924 | 0 | 0 | No | No | Yes | 0 |
| Andrew Pierce | January 26, 1991 | 0 | 0 | No | No | Yes | 2013 |
| Daniel Pierce | 1957 | 0 | 0 | No | No | Yes | 1978 |
| George Pierce | January 10, 1888 | 1912 | 1917 | Yes | Yes | No | 0 |
| Jack Pierce | December 15, 1936 | 0 | 0 | No | No | Yes | 0 |
| Walt Pierce | April 4, 1958 | 0 | 0 | No | No | Yes | 1976 |
| Adolph Pierotti | 0 | 0 | No | No | Yes | 0 | |
| Jim Piersall | November 14, 1929 | 1950 | 1967 | Yes | No | No | 0 |
| Larry Pierson | February 10, 1965 | 0 | 0 | No | No | Yes | 1987 |
| Verle Pierson | December 27, 1921 | 0 | 0 | No | No | Yes | 0 |
| A.J. Pierzynski | December 30, 1976 | 1998 | 2016 | Yes | Yes | No | 0 |
| Henry Piestrak | 1919 | 0 | 0 | No | No | Yes | 0 |
| Louis Pietranera | December 4, 1918 | 0 | 0 | No | No | Yes | 0 |
| Wayne Pietri | February 27, 1942 | 0 | 0 | No | No | Yes | 0 |
| Lip Pike | May 25, 1845 | 1871 | 1887 | Yes | Yes | No | 0 |
| Mark Pike | 0 | 0 | No | No | Yes | 0 | |
| Tyler Pike | January 26, 1994 | 0 | 0 | No | No | Yes | 0 |
| Pilcher | 0 | 0 | No | No | Yes | 0 |